COBIMETINIB

COBIMETINIB

Capsule

COBIMETINIB 20 MG CAPSULE
Cobimetinib is a fumarate salt appearing as white to off-white solid and exhibits a pH dependent solubility. 297 COTELLIC (cobimetinib) tablets are supplied as white, round, film-coated 20 mg tablets for oral 298 administration, debossed on one side with “COB”. Each 20 mg tablet contains 22 mg of cobimetinib 299 fumarate, which corresponds to 20 mg of the cobimetinib free base. 300 The inactive ingredients of COTELLIC are: Tablet Core: microcrystalline cellulose, lactose monohydrate, 301 croscarmellose sodium, magnesium stearate. Coating: polyvinyl alcohol, titanium dioxide, polyethylene 302 glycol
COTELLIC (Cobimetinib) : 20 mg
As per Recommendation by Company: *Confirm the presence of BRAF V600E or V600K mutation in tumor specimens prior to initiation of COTELLIC. *The recommended dose is 60 mg orally once daily for the first 21 days of each 28-day cycle until disease progression or unacceptable toxicity. Take COTELLIC with or without food.
COTELLIC is a kinase inhibitor indicated for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib.